Antidiabetic drugs “gliptins” affect biofilm formation by the cariogenic bacterium Streptococcus mutans through inhibition of the bacterial DPP IV-like enzyme. Authors
نویسندگان
چکیده
Arpan De, Arianna Pompilio, Jenifer Francis, Iain C. Sutcliffe, Gary W. Black, Giulio Lupidi, Dezemona Petrelli, Luca A. Vitali* Authors’ affiliation 1. School of Pharmacy, University of Camerino, Camerino, Italy. 2. Department of Medical, Oral and Biotechnological Sciences, School of Medicine, "G. d'Annunzio" University of Chieti-Pescara 3. Center of Excellence on Ageing, "G. d'Annunzio" University Foundation, Chieti. 4. Department of Applied Sciences, Faculty of Health & Life Sciences, Northumbria University, Newcastle upon Tyne, UK 5. School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.
منابع مشابه
d-Alanine metabolism is essential for growth and biofilm formation of Streptococcus mutans.
Part of the d-alanine (d-Ala) metabolic pathway in bacteria involves the conversion of l-alanine to d-Ala by alanine racemase and the formation of d-alanyl-d-alanine by d-alanine-d-alanine ligase, the product of which is involved in cell wall peptidoglycan synthesis. At present, drugs that target the metabolic pathway of d-Ala are already in clinical use - e.g. d-cycloserine (DCS) is used as an...
متن کاملTriethylene Glycol Up-Regulates Virulence-Associated Genes and Proteins in Streptococcus mutans
Triethylene glycol dimethacrylate (TEGDMA) is a diluent monomer used pervasively in dental composite resins. Through hydrolytic degradation of the composites in the oral cavity it yields a hydrophilic biodegradation product, triethylene glycol (TEG), which has been shown to promote the growth of Streptococcus mutans, a dominant cariogenic bacterium. Previously it was shown that TEG up-regulated...
متن کاملEvaluation of inhibitory effects of Chlorella vulgaris extract on growth, proliferation and biofilm formation by Streptococcus mutans and evaluation of its toxicity
Background & Objectives: Dental caries is the most important disease caused by some bacteria specially Streptococcus Mutans from Viridans family. The aim of this study is to evaluate the inhibitory effect of Chlorella vulgaris extract on growth, proliferation, and biofilm formation of Streptococcus mutans. Materials & Methods: Microalgae Chlorella vulgaris was extracted via maceration using ch...
متن کاملEnterococcus faecium WB2000 Inhibits Biofilm Formation by Oral Cariogenic Streptococci
This study investigated the inhibitory effect of probiotic Enterococcus faecium WB2000 on biofilm formation by cariogenic streptococci. The ability of E. faecium WB2000 and JCM5804 and Enterococcus faecalis JCM5803 to inhibit biofilm formation by seven laboratory oral streptococcal strains and 13 clinical mutans streptococcal strains was assayed. The Enterococcal strains inhibited biofilm forma...
متن کاملNutritionally Variant Streptococci Interfere with Streptococcus mutans Adhesion Properties and Biofilm Formation.
The bacterial species Streptococcus mutans is known as the main cause of dental caries in humans. Therefore, much effort has focused on preventing oral colonization by this strain or clearing it from oral tissues. The oral cavity is colonized by several bacterial species that constitute the commensal oral flora, but none of these is able to interfere with the cariogenic properties of S. mutans....
متن کامل